The Ice Bucket Challenge is trending again after ALS breakthrough

At Project MinE, a team of 80 worldwide researchers conducted the largest-ever study of amyotrophic lateral sclerosis with over 15,000 patients. Here they linked a gene known as NEK1 to familial ALS, which accounts for around 10 percent of cases.

Following the news, Twitter users have been re-sharing images and videos of their previous icy escapades — which attracted celebrities like Cristiano Ronaldo and Ashton Kutcher.

ALS — also known as motor neurone disease — affects the nervous system in the brain and spine. Those affected slowly lose muscle control and can be fully paralysed as little as two years after they are diagnosed.

The research project is one of six funded by Ice Bucket Challenge donations. That summer, 17 million people filmed themselves being drenched in icy water. One in six British people took part at the time. Meanwhile, the U.K. charity Motor Neurone Disease Association also received £4 million ($5.2 million) in donations from a Kickstarter page.

Other charities that have found success with so-called “slacktivism” campaigns include Cancer Research U.K., which received £8 million after people nominated friends to take a no-makeup selfie.

However, research carried out by John Hopkins Carey Business School the found that in many cases social media buzz does not often translate to donations. Only 64 percent of the 3,500 people in the study who broadcasted a pledge actually followed through with the cash.

#IceBucketChallenge @NDmom @espngolic @Espngreeny pic.twitter.com/92Vb6YqZhA

— StacyGSGreenberg (@StacyGSG) July 27, 2016

https://twitter.com/JulieS/status/758243476752441344

Great news that #IceBucketChallenge ? raised led to breakthrough for @alsassociation. Re-live @CCGilesYork's turn ? pic.twitter.com/JsONPpJNgu

— Sussex Police (@sussex_police) July 27, 2016

We had a blast doing the #icebucketchallenge in 2014. So glad to hear that so much good came from this movement. pic.twitter.com/gVFfRliYhL

— Jan Dils, Attorneys at Law (@JanDilsAttorney) July 27, 2016

#IceBucketChallenge funds ALS breakthrough ? #UNCMBAs raised $1k+ …Thanks for the assist, @ChapelHillFD! #teamworkhttps://t.co/Pioiz3jqZ2

— UNC Kenan-Flagler (@kenanflagler) July 27, 2016